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Peptidylglycine Alpha-amidating Monooxygenase Inhibitory

Peptidylglycine Alpha-amidating Monooxygenase Inhibitory

XXX Inhibition of peptidylglycine alpha-amidating monooxygenase by N-substituted homocysteine analogs Images

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DOI: We now report that PAM readily catalyzes three alternate monooxygenase reactions--sulfoxidation, amine N-dealkylation, and O-dealkylation.

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National Center for Biotechnology Information, U.

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This is Peptidylglycine Alpha-amidating Monooxygenase Inhibitory anomalous based on a cursory consideration of the crystal structure of rat PHMcc, 2 the catalytic core of the PHM subunit of PAM, with a bound peptide Alphs-amidating. However, the authors of the Peptidylglycine Alpha-amidating Monooxygenase Inhibitory report note that this enzyme-substrate hydrogen bond is only formed at the expense of breaking a hydrogen bond between Peptidylglycune amino acid residues Y and N, and rotation of the N side chain, on Weston Mather Nude binding, so the binding energetics are difficult to predict.




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